The series revolves around Nyarome, who gets into mischief and situations with his buddies Kemunpas and Beshi in modern day Tokyo. The three are joined by many newly-created characters, including the melon-cat hybrid Nyanmelo and a Lion. As with previous Fujio Pro gag series, any chaos that may occur in chapters can be swept clean for the next story but there are some developments that can carry forth: Besides the additions of Nyanmelo and Lion to the cast, Nyarome's edgy rapper alter-ego "Waru-Nyaro" splits off from him to become his own entity by the end of the series.