Lupo, a lone human, wanders the surface of a gigantic ship, trying to survive and encounter the aliens who abducted him nearly 50 years ago. He faces contamination by a hostile organism transforming all forms of life into mutated creatures and causing major malfunctions to the ship. Is this what forces the extra-terrestrials to retreat into the bowels of the ship, behind monumental doors, impassable to anyone else? Left to his own devices in a universe beyond him, man will have to compete in intelligence and perseverance to unravel the mysteries of his very existence! Inspired by the manga Blame!